Arthropodicidal oxazolines

ABSTRACT

PCT No. PCT/US93/03563 Sec. 371 Date Oct. 19, 1994 Sec. 102(e) Date Oct. 19, 1994 PCT Filed Apr. 21, 1993 PCT Pub. No. WO93/21165 PCT Pub. Date Oct. 28, 1993.Arthropodicidal compounds, compositions and methods of use of compounds having formula (I) wherein A, G, Z and R1 to R4, are as defined in the text.

This application is a 371 of PCT US 93/03563 filed on Apr. 21, 1993 which is a continuation of application Ser. No. 07/976,587, filed Nov. 16, 1992, now abandoned, which is a continuation of application Ser. No. 07/872,493, filed Apr. 23, 1992, now abandoned.

This invention pertains to spirocyclic oxa- and thia-zolines as arthropodicides. EP 345,775 and EP 432,661 disclose non-spirocyclic oxa- and thia-zolines as insecticides.

SUMMARY OF THE INVENTION

The invention pertains to compounds of Formula I, including all geometric and stereoisomers, agriculturally suitable salts thereof, agricultural compositions containing them and their use as arthropodicides in both agronomic and nonagronomic environments. The compounds are ##STR1## wherein A is selected from the group a direct bond, O, S, --XCH₂ -- and C₁ -C₃ straight or branched chain alkylene; when A is --XCH₂ --, the point of attachment to the phenyl ring is X or CH₂ ;

G is selected from the group O, S, --CH₂ --Y--CH₂ --, --Y(CH₂)_(m) -- and C₁ -C₃ straight or branched chain alkylene; when G is --Y(CH₂)_(m) --, the point of attachment to the phenyl ring is Y or the terminal carbon, and the ring containing A and G has 5-7 members;

X and Y are independently selected from the group O and S;

Z is selected from the group O and S;

R¹ is selected from the group H, halogen, C₁ -C₆ alkyl, C₁ -C₆ alkoxy, C₁ -C₆ haloalkyl and C₁ -C₆ haloalkoxy;

R² is selected from the group H, halogen, C₁ -C₁₆ alkyl, C₃ -C₇ cycloalkyl, C₄ -C₇ cycloalkylalkyl, C₁ -C₁₆ haloalkyl. C₂ -C₁₆ alkenyl, C₂ -C₁₆ haloalkenyl, C₂ -C₁₆ alkynyl, C₂ -C₁₆ haloalkynyl, C₂ -C₁₆ alkoxyalkoxy, OR⁵, R⁵ OC(O)--, R⁵ C(O)-- and ##STR2## W is selected from the group direct bond, S, O, C(═O), C(═O)O, C(═O)O--C₁ -C₂ alkylene, C₁ -C₄ alkylene, O--C₁ -C₄ alkylene and O--C₂ -C₄ alkenylene, wherein when W is O--C₁ -C₄ alkylene or O--C₂ -C₄ alkenylene, the oxygen atom can be attached to either aromatic ring and when W is C(═O)O or C(═O)O--C₁ -C₂, the C(═O) moiety can be attached to either aromatic ring;

Q is selected from CH and N;

R³ and R⁴ are independently selected from the group H, halogen, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₁ -C₆ haloalkoxy, C 1-C₆ alkylthio, CN and NO₂ ;

R⁵ is selected from the group H, C₃ -C₇ cycloalkyl, C₄ -C₁₆ cycloalkylalkyl, C₁ -C₁₆ alkyl, C₁ -C₁₆ haloalkyl, C₂ -C₁₆ alkenyl, C₂ -C₁₆ haloalkenyl, C₂ -C₁₆ alkynyl and C₂ -C₁₆ haloalkynyl;

R⁶ is selected from the group halogen, C₁ -C₁₀ alkyl, C₁ -C₁₀ alkoxy, C₁ -C₁₀ haloalkyl, C₁ -C₁₀ haloalkoxy and Si(R⁷)(R⁸)R⁹ ;

R⁷, R⁸ and R⁹ are independently C₁ -C₃ alkyl;

m is 1 or 2; and

n is 0 or an integer from 1 to 5.

Preferred Compounds A are compounds of Formula I wherein:

A is a direct bond;

G is selected from the group C₂ -C₃ alkylene, --CH₂ --Y--CH₂ --, and --Y(CH₂)_(m) --;

R¹ is selected from the group H and halogen; and

R³ and R^(a) are independently selected from the group H, F and Cl.

Specifically preferred for biological activity is the compound of Preferred A which is

2'-(2,6-difluorophenyl)-3,4-dihydro-6-octyloxyspiro-[naphthalene-1(2H),4'(5'H)-oxazole].

Compounds of this invention can exist as one or more stereoisomers. The various stereoisomers include enantiomers, diastereomers and geometric isomers. One skilled in the an will appreciate that one stereroisomer may be more active than the others and how to separate stereoisomers. Accordingly, the present invention comprises racemic mixtures, individual stereoisomers, and optically active mixtures of compounds of Formula I as well as their agriculturally suitable salts.

In the above recitations, the term "alkyl" used either alone or in compound word such as "alkylthio" or "haloalkyl", denotes straight or branched alkyl such as methyl, ethyl, n-propyl, isopropyl and the different butyl, pentyl and hexyl isomers. Similarly, the terms "alkylene" and "alkenylene" denote straight or branched chain groups.

Alkoxy denotes methoxy, ethoxy, n-propyloxy, isopropyloxy and the different butoxy, pentoxy and hexyloxy isomers. Alkenyl denotes straight or branched chain alkenes such as vinyl, 1-propenyl, 2-propenyl, and the different butenyl, pentenyl and hexenyl isomers. Alkynyl denotes straight chain or branched alkynes such as ethynyl,1-propynyl, 3-propynyl and the different butynyl, pentynyl and hexynyl isomers. Cycloalkyl denotes cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.

The term "halogen", either alone or in compound words such as "haloalkyl", denotes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as "haloalkyl" said alkyl may be partially or fully substituted with halogen atoms, which may be the same or different. Examples of haloalkyl include CH₂ CH₂ F, CF₂ CF₃ and CH₂ CHFCl. The terms "haloalkenyl" and "haloalkynyl" are defined analogously to the term "haloalkyl".

The total number of carbon atoms in a substituent group is indicated by the "C_(i) -C_(j) " prefix where i and j are numbers from 1 to 16. For example, C₄ alkoxyalkoxy designates the various isomers of an alkoxy group substituted with a second alkoxy group containing a total of 4 carbon atoms, examples including OCH₂ OCH₂ CH₂ CH₃ and OCH₂ CH₂ OCH₂ CH₃. When a compound is substituted with a substituent bearing a subscript indicated by a lower case letter which allows the number of said substituents to exceed 1, said substituent (when they exceed 1) are independently selected from the group of defined substituents.

DETAILS OF THE INVENTION

Compounds of Formula I are prepared as described in Schemes 1 through 6 with substituents as previously defined, unless otherwise noted. Compounds of Formula I can be prepared by treatment of Formula II compounds with a dehydrating agent such as sulfuric acid, polyphosphoric acid, phosphorous pentoxide, thionyl chloride, dicyclohexylcarbodiimide and phosphorous pentasulfide. Sulfuric acid. polyphosphoric acid, phosphorous pentoxide, thionyl chloride and dicyclohexylcarbodiimide produce Formula I compounds where X is oxygen. while use of phosphorous pentasulfide produces Formula I compounds where X is sulfur. Typical reactions involve the combination of a Formula II compound with an excess molar amount of the dehydrating agent (1.1 equivalents to 20 equivalents) in the presence or absence of a solvent such as benzene, toluene, xylene, chlorobenzene or dichlorobenzene. The reaction temperature can vary from 0° C. to the reflux temperature of the solvent being used. The reaction is usually complete in 24 hours. Alternatively, this transformation can be achieved by treatment of Formula II compounds with triphenylphosphine and carbon tetrachloride in the presence of a tertiary amine base such as methylamine. The reaction can be run in a suitable solvent such as acetonitrile. The reaction temperature can vary from about 0° C. to 60° C. The reaction is usually complete in 24 hours. (See Tetrahedron Letters, (1981), 22,4471). Scheme 1 illustrates this transformation. ##STR3##

Compounds of Formula II can be prepared by the reaction of an aminoalcohol III with a substituted acid chloride of Formula IV in equimolar proportions in the presence of an excess of an acid scavenger, such as tertiary alkylamines or pyridines, in an aprotic organic solvent such as ether, tetrahydrofuran, chloroform, methylene chloride, benzene or toluene. The reaction temperature can vary from about -20° C. to 100° C. with 0° C. to 50° C. being preferred. The reaction is generally complete after 24 hours. Scheme 2 illustrates this transformation. ##STR4##

Compounds of Formula III can be prepared by the reduction of Formula V compounds. Typical reactions involve combination of an excess in molar amounts of a reducing agent (4 equivalents to 10 equivalents) such as lithium aluminum hydride with one equivalent of a Formula V compound m a solvent such as tetrahydrofuran or ether. The reaction temperatures can vary from about 0° C. to the reflux temperature of the particular solvent being used. This transformation is illustrated in Scheme 3. ##STR5##

Compounds of Formula V can be prepared by the hydrolysis of hydantoins

of Formula VI. A typical reaction involve combination of a Formula VI compound with an excess in molar amounts (2 equivalents to 20 equivalents) of a base such as barium hydroxide, potassium hydroxide or sodium hydroxide in a solvent such as water, methanol, ethanol or isopropanol. The reaction temperature can vary from about 50° C. to the reflux temperature of the particular solvent being used. The reaction time can vary from about 24 hours to ten days. Scheme 4 illustrates this transformation. ##STR6##

Compounds of Formula VI can be prepared from Formula VII compounds. Treatment of a Formula VII compound with an excess of potassium cyanide or sodium cyanide and ammonium carbonate in a solvent such as ethanol, methanol and/or water, produces compounds of Formula VI (See J. Med. Chem., 1988, 31, 230). This transformation is illustrated in Scheme 5. ##STR7##

The starting ketones of Formula VII are known in the art or can be obtained by methods analogous to known procedures. Those skilled in the art will recognize the Formula VII compounds to include indanones, tetralones, chromanones, thiochromanones, benzofuran-3-ones, isochromanones and others.

Alternatively, compounds of Formula I (where R² is --OR⁵ or R⁵ C(O)O--) can be prepared by the reaction of compounds of the Formula VIII with an electrophile of Formula IX in the presence of a suitable base such as alkali metal, alkali alkoxide, tertiary amine or metal hydride. The reaction can be run in a conventional organic solvent such as chloroform, methylene chloride, tetrahydrofuran, ether or dimethylformamide. The reaction temperature can vary from about -10° C. to 100° C. This transformation is illustrated in Scheme 6. ##STR8##

The preparation of Formula VIII compounds can be accomplished by cleavage of Formula I compounds (where R² is OMe). Ether cleavages are known in the an and a comprehensive review can be found in Synthesis, 1983, 249.

EXAMPLE 1 Step A: 3',4'-dihydro-6'-methoxyspiro[imidazolidine-4,1'(2'H)-naphthalene]-2,5-dione

A mixture of 35.2 g (0.2 mol) of 6-methoxy-1-tetralone, 19.5 g (0.3 mol) of potassium cyanide and 134.4 g (1.4 mol) of ammonium carbonate in 280 mL of EtOH was placed in a stainless steel bomb and heated at 110° C. for 48 hours. After cooling, the mixture was poured in 1.4 L of water. It was allowed to sit at ambient temperature for 3 days. The precipitated solid was filtered and washed several times with water and dried to give 48.1 g of a brown solid: mp 218°-220° C. ¹ H-NMR (DMSO-d₆)d10.75(s, 1H),8.45(s, 1H),6.96(d, 1H),6.79 (d, 1H), 6.70 (s, 1H), 3.72 (s, 3H), 2.73 (t, 2H), 1.70-2.20 (m, 4H).

Step B: 1-amino-1,2,3,4-tetrahydro-6-methoxy-1-naphthalenecarboxylic acid

To a suspension of 2.95 g (0.012 mol) of the product of Step A in 100 mL of water was added 15.1 g (0.0479 mol) of barium hydroxide octahydrate. The reaction was heated at reflux for 3 days. To the reaction mixture was carefully added 6.4 g (0.067 mol) of ammonium carbonate. Refluxing was continued for another 2 hours. The solid was filtered off while hot and the pH of the filtrate adjusted to 6. The filtrate was then concentrated to give 1.86 g of a tan solid: mp>250° C. ¹ H NMR (D₂ O) d 7.20 (d, 1H), 6.85 (d and s, 2H), 3.835 (s, 3H), 2.85 (t, 2H), 1.70-2.40 (m, 4H).

Step C: 1-amino-1,2,3,4-tetrahydro-6-methoxy-1-naphthalenemethanol

To a suspension of 172 mg (0.00452 mol) of lithium aluminum hydride in 6 mL of THY at 0° C. was added portion-wise 500 mg (0.00226 mol) of the product of Step B. The mixture was refluxed overnight. EtOAc was carefully added to quench excess hydride and 50% aqueous NaOH added. The mixture was extracted with EtOAc and the EtOAc extract washed with brine. It was dried (MgSO₄) and concentrated to give an oil which solidified on standing to give 390 mg of a tan solid: mp 89°-95.6° C. ¹ H NMR (DMSO-d₆) d 7.422 (d, 1H), 6.70 (d, 1H), 6.95 (s, 1H), 3.690 (s, 3H), 3.20-3.40 (m, 3H), 2.70 (t, 2H), 2.0-2.20 (m. 2H), 1.70 (m, 2H).

Step D: 2,6-difluoro-N-[1,2,3,4-tetrahydro-1-(hydroxymethyl)-6-methoxy-1-naphthalenyl]benzamide

To a stirring mixture of 2.0 g (0.00965 mol) of the product of Step C, 976 mg (0.00965 mol) of methylamine in 30 mL of THF at 0° C. was added dropwise a solution of 2,6-difluorobenzoylchloride in 15 mL of THF. The reaction mixture was stirred at ambient temperature for 30 minutes. The precipitated triethylamine hydrochloride was filtered off and the filtrate concentrated. It was purified by passing through a silica gel column eluting with EtOAc:Hexane (2:3) to afford a white solid: mp 174°-175° C. 1H NMR (CDCl₃) d 7.30 (m, 2H), 6.90 (t, 2H), 6.85 (dd, 1H), 6.60 (d, 1H), 6.35 (broad s, 1H), 4.80 (dd, 1H), 4.20 (dd, 1H), 3.77 (s, 3H), 3.75 (d, 2H), 2.80 (m, 2H), 2.30 (m, 2H), 1.90 (m, 2H).

Step E: 2'-(2,6-difluorophenyl)-3,4-dihydro-6-methoxy spiro [naphthalene-1(2H),4'(5'H)-oxazole]

To a suspension of 600 mg (0.0017 mol) of the product of Step D in 9 mL of acetonitrile was added 1.8 mL CCl₄ and 264 mg (0.0026 mol) of methylamine. Then, 678 mg (0.0026 mol) of triphenylphosphine was added. The mixture was stirred at ambient temperature for 15 minutes.

The precipitated triphenylphosphine oxide was filtered and the filtrate concentrated. The residue was purified by passing through a silica gel column eluting with methylene chloride to give 520 mg of an oil which solidified on standing: mp 64°-67° C. ¹ H NMR (CDCl₃) d 7.40 (m, 1H), 7.25 (d, 1H), 6.99 (m, 2H), 6.80 (dd, 1H), 6.62 (d, 1H), 4.25 (dd, 2H), 3.79 (s, 3H), 2.80 (m, 2H), 1.75-2.20 (m, 4H).

Step F: 2'-(2,6-difluorophenyl)-3,4-dihydrospiro [naphthalene-1(2H), 4'(5'H)-oxazole]-6-ol

Aluminum chloride, 600 mg (0.00764 mol), was added to 5 mL of ethanethiol at 0° C. Then, 250 mg (0.0076 mol) of the product of Step E was added at once. The reaction was stirred at 0° C. for 10 minutes. It was quenched with MeOH at 0° C., poured into saturated aqueous NaHCO₃ solution and extracted with EtOAc:THF (1:1). The combined extracts were dried (MgSO4) and concentrated to give 230 mg of a white solid. ¹ H NMR (DMSO-d₆) d 9.31 (s, 1H), 7.65 (m, 1H), 7.27 (t, 2H), 6.96 (d, 1H), 6.60 (dd, 1H), 6.49 (d, 1H), 4.35 (dd, 2H), 2.70 (broad, 2H), 1.70-2.0 (m, 4H).

Step G: 2'-(2,6-difluorophenyl)-3,4-dihydro-6-octyloxyspiro[naphthalene-1(2H), 4'( 5'H)-oxazole]

To a suspension of 64 mg (0.00127 mol) of NaH in 1 mL of DMF at 0° C. was added a partial solution of 200 mg (0.00063 mol) of the product of Step F. The reaction was stirred at 0° C. for 30 minutes. Then, 304 mg (0.00127 mol) of 1-iodooctane was added and stirring continued for an additional 30 minutes at 0° C. The reaction mixture was poured into ice-water and extracted with Et₂ O. The Et₂ O extract was washed with brine, dried (MgSO₄) and concentrated. The residue was purified by passing through a silica gel column eluting with EtOAc:Hexanes (1:4) to give 240 mg of a clear oil. ¹ H NMR (CDCl₃) d 7.40 (m, 1H), 7.20 (d, 1H), 6.98 (Ab q, 2H), 3.92 (t, 2H), 2.80 (m, 2H), 1.70-2.20 (m, 4 H), 1.20-1.45 (m, 12H), 0.90 (t, 3H).

By the procedures described herein the compounds of Tables 1 to 8 can be prepared. The compounds in Table 1, row 1 can be referred to as 1-1-1, 1-1-2 and 1-1-3 (as designated by Table number, line number and column number). All of the other specific compounds covered in these Tables can be designated in an analogous manner by Table, line and column. Abbreviations used in Tables: Ph=phenyl, Py=2-pyridyl. ##STR9##

                                      TABLE 1                                      __________________________________________________________________________     Column 1     Column 2     Column 3                                             __________________________________________________________________________     Z = O, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                   1 H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         2 6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         3 6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        4 6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        5 6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                    6 6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                           7 6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         8 6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        9 6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                     10                                                                               6-OPy     6-CH.sub. 2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                  6-OCH.sub.2 CH═CH--CH.sub.2 Ph                    11                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         12                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        13                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3           14                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         15                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              16                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              17                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              18                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              19                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub. 2).sub.7 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              20                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              21                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              22                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              23                                                                               6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              24                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              25                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              26                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              27                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              28                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              29                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              30                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-Cl, R.sup.2 =                  31                                                                               H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         32                                                                               6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         33                                                                               6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        34                                                                               6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        35                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                    36                                                                               6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                           37                                                                               6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         38                                                                               6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        39                                                                               6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                     40                                                                               6-OPy     6-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   6-OCH.sub.2 CH═CH--CH.sub.2 Ph                    41                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         42                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        43                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3           44                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         45                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub. 2).sub.2 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              46                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              47                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              48                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              49                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              50                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              51                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              52                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                               53                                                                              6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              54                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              55                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              56                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              57                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              58                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              59                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              60                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = H, R.sup.3 = 2'-Cl, R.sup.4 = 6'-Cl, R.sup.2 =                 61                                                                               H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         62                                                                               6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         63                                                                               6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        64                                                                               6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        65                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                    66                                                                               6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                           67                                                                               6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         68                                                                               6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        69                                                                               6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                     70                                                                               6-OPy     6-CH.sub. 2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                  6-OCH.sub.2 CH═CH--CH.sub.2 Ph                    71                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         72                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        73                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3           74                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         75                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              76                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              77                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              78                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              79                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub. 2).sub.7 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              80                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              81                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              82                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              83                                                                               6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              84                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              85                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              86                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              87                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              88                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              89                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              90                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = S, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                   91                                                                               H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         92                                                                               6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         93                                                                               6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        94                                                                               6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        95                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                    96                                                                               6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                           97                                                                               6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         98                                                                               6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        99                                                                               6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                    100                                                                               6-OPy     6-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   6-OCH.sub.2 CH═CH--CH.sub.2 Ph                   101                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        102                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       103                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          104                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        105                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub. 2                                      CH.sub.3                                             106                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             107                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             108                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             109                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             110                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             111                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             112                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             113                                                                               6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub. 2                                                      6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             114                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             115                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             116                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             117                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             118                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             119                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             120                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = S, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-Cl, R.sup.2 =                 121                                                                               H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        122                                                                               6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        123                                                                               6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       124                                                                               6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3       125                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                   126                                                                               6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                          127                                                                               6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        128                                                                               6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3       129                                                                               6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                    130                                                                               6-OPy     6-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   6-OCH.sub.2 CH═CH--CH.sub.2 Ph                   131                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        132                                                                               7-CF.sub. 3                                                                              7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       133                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          134                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        135                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             136                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             137                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             138                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             139                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             140                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub. 2                                      CH.sub.3                                             141                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             142                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             143                                                                               6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             144                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             145                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             146                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             147                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             148                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub. 2                                                      6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             149                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             150                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-Cl, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =               151                                                                               H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        152                                                                               6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        153                                                                               6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       154                                                                               6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3       155                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                   156                                                                               6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                          157                                                                               6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        158                                                                               6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3       159                                                                               6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                    160                                                                               6-OPy     6-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   6-OCH.sub.2 CH═CH--CH.sub.2 Ph                   161                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        162                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       163                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          164                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        165                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             166                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             167                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             168                                                                               6-O(CH.sub.2).sub. 8 CH.sub.3                                                            6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             169                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             170                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             171                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             172                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             173                                                                               6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             174                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             175                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub. 2                                       CH.sub.3                                             176                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             177                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             178                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             179                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             180                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-Cl, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =               181                                                                               H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        182                                                                               6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        183                                                                               6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       184                                                                               6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3       185                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                   186                                                                               6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                          187                                                                               6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        188                                                                               6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3       189                                                                               6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                    190                                                                               6-OPy     6-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   6-OCH.sub.2 CH═CH--CH.sub.2 Ph                   191                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        192                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       193                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          194                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        195                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub. 3).sub.2                                                     6-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             196                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             197                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             198                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             199                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             200                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             201                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             202                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             203                                                                               6-(CH.sub.2).sub. 5 CH.sub.3                                                             6-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             204                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             205                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             206                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             207                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             208                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             209                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             210                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub. 2                                       CH.sub.3                                             Z = O, R.sup.1 = 8-F, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                211                                                                               H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        212                                                                               6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        213                                                                               6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       214                                                                               6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3       215                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                   216                                                                               6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                          217                                                                               6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        218                                                                               6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3       219                                                                               6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                    220                                                                               6-OPy     6-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   6-OCH.sub.2 CH═CH--CH.sub.2 Ph                   221                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        222                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       223                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          224                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        225                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             226                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             227                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             228                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             229                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             230                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub. 3).sub.2                                                     6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             231                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             232                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             233                                                                               6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             234                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             235                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             236                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             237                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             238                                                                               6-(CH.sub.2).sub. 11 CH.sub.3                                                            6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             239                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             240                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-F, R.sup.3 = 2'-F, R.sup.4 = 6'-Cl, R.sup.2 =               241                                                                               H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        242                                                                               6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        243                                                                               6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       244                                                                               6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3       245                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                   246                                                                               6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                          247                                                                               6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd. C--(CH.sub.2).sub.4 CH.sub.3       248                                                                               6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3       249                                                                               6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                    250                                                                               6-OPy     6-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   6-OCH.sub.2 CH═CH--CH.sub.2 Ph                   251                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        252                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       253                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          254                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        255                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             256                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             257                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub. 3)CH.sub.2                                      CH.sub.3                                             258                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             259                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             260                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             261                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             262                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             263                                                                               6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             264                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             265                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub. 3).sub.2                                                      6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             266                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             267                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             268                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             269                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             270                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2              __________________________________________________________________________                               CH.sub.3                                        

                                      TABLE 2                                      __________________________________________________________________________     Column 1     Column 2     Column 3                                             __________________________________________________________________________     Z = O, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                   1 H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         2 6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         3 6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        4 6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        5 6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                    6 6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                           7 6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         8 6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        9 6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                     10                                                                               6-OPy     6-CH.sub. 2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                  6-OCH.sub.2 CH═CH--CH.sub.2 Ph                    11                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         12                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        13                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3           14                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         15                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              16                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              17                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              18                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              19                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub. 2).sub.7 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              20                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              21                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              22                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              23                                                                               6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              24                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              25                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              26                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              27                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              28                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              29                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              30                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-Cl, R.sup.2 =                  31                                                                               H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         32                                                                               6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         33                                                                               6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        34                                                                               6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        35                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                    36                                                                               6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                           37                                                                               6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         38                                                                               6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        39                                                                               6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                     40                                                                               6-OPy     6-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   6-OCH.sub.2 CH═CH--CH.sub.2 Ph                    41                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         42                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        43                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3           44                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         45                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub. 2).sub.2 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              46                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              47                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              48                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              49                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              50                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              51                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              52                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                               53                                                                              6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              54                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              55                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              56                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              57                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              58                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              59                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              60                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = S, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                   61                                                                               H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         62                                                                               6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         63                                                                               6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        64                                                                               6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        65                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                    66                                                                               6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                           67                                                                               6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         68                                                                               6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        69                                                                               6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                     70                                                                               6-OPy     6-CH.sub. 2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                  6-OCH.sub.2 CH═CH--CH.sub.2 Ph                    71                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         72                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        73                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3           74                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         75                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              76                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              77                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              78                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              79                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub. 2).sub.7 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              80                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              81                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              82                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              83                                                                               6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              84                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              85                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              86                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              87                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              88                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              89                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              90                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-Cl, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                91                                                                               H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         92                                                                               6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         93                                                                               6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        94                                                                               6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        95                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                    96                                                                               6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                           97                                                                               6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         98                                                                               6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        99                                                                               6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                    100                                                                               6-OPy     6-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   6-OCH.sub.2 CH═CH--CH.sub.2 Ph                   101                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        102                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       103                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          104                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        105                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub. 2                                      CH.sub.3                                             106                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             107                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             108                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             109                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             110                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             111                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             112                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             113                                                                               6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub. 2                                                      6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             114                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             115                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             116                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             117                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             118                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             119                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             120                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-F, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                121                                                                               H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        122                                                                               6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        123                                                                               6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       124                                                                               6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3       125                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                   126                                                                               6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                          127                                                                               6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        128                                                                               6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3       129                                                                               6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                    130                                                                               6-OPy     6-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   6-OCH.sub.2 CH═CH--CH.sub.2 Ph                   131                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        132                                                                               7-CF.sub. 3                                                                              7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       133                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          134                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        135                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             136                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             137                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             138                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             139                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             140                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub. 2                                      CH.sub.3                                             141                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             142                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             143                                                                               6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             144                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             145                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             146                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             147                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             148                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub. 2                                                      6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             149                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             150                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2              __________________________________________________________________________                               CH.sub.3                                        

                                      TABLE 3                                      __________________________________________________________________________     Column 1     Column 2     Column 3                                             __________________________________________________________________________     Z = O, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                   1 H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         2 6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         3 6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        4 6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        5 6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                    6 6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                           7 6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         8 6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        9 6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                     10                                                                               6-OPy     6-CH.sub. 2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                  6-OCH.sub.2 CH═CH--CH.sub.2 Ph                    11                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         12                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        13                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3           14                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         15                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              16                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              17                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              18                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              19                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub. 2).sub.7 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              20                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              21                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              22                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              23                                                                               6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              24                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              25                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              26                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              27                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              28                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              29                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              30                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-Cl, R.sup.2 =                  31                                                                               H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         32                                                                               6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         33                                                                               6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        34                                                                               6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        35                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                    36                                                                               6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                           37                                                                               6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         38                                                                               6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        39                                                                               6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                     40                                                                               6-OPy     6-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   6-OCH.sub.2 CH═CH--CH.sub.2 Ph                    41                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         42                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        43                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3           44                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         45                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub. 2).sub.2 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              46                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              47                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              48                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              49                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              50                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              51                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              52                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                               53                                                                              6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              54                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              55                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              56                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              57                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              58                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              59                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              60                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-Cl, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                61                                                                               H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         62                                                                               6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         63                                                                               6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        64                                                                               6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        65                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                    66                                                                               6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                           67                                                                               6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         68                                                                               6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        69                                                                               6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                     70                                                                               6-OPy     6-CH.sub. 2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                  6-OCH.sub.2 CH═CH--CH.sub.2 Ph                    71                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         72                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        73                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3           74                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         75                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              76                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              77                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              78                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              79                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub. 2).sub.7 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              80                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              81                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              82                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              83                                                                               6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              84                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              85                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              86                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              87                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              88                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              89                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              90                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-F, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                 91                                                                               H         6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         92                                                                               6-Cl      6-(4-F--Ph)  6-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         93                                                                               6-F       6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        94                                                                               6-Br      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        95                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph-4-F                                                                           6-OCH.sub.2 Ph-4-F                                    96                                                                               6-Ph      6-CH.sub.2 Ph-4-Cl                                                                          6-OCH.sub.2 CH.sub.2 Ph-4-F                           97                                                                               6-Py      6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         98                                                                               6-OPh     6-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          6-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        99                                                                               6-SPh     6-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   6-CH.sub.2 CH═CH--CH.sub.2 Ph                    100                                                                               6-OPy     6-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   6-OCH.sub.2 CH═CH--CH.sub.2 Ph                   101                                                                               7-Cl      7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        102                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       103                                                                               7-Ph      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          104                                                                               7-OPh     7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        105                                                                               6-O(CH.sub.2).sub.5 CH.sub.3                                                             6-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub. 2                                      CH.sub.3                                             106                                                                               6-O(CH.sub.2).sub.6 CH.sub.3                                                             6-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             107                                                                               6-O(CH.sub.2).sub.7 CH.sub.3                                                             6-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             108                                                                               6-O(CH.sub.2).sub.8 CH.sub.3                                                             6-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             109                                                                               6-O(CH.sub.2).sub.9 CH.sub.3                                                             6-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             110                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             111                                                                               6-O(CH.sub.2).sub.15 CH.sub.3                                                            6-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     6-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             112                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             113                                                                               6-(CH.sub.2).sub.5 CH.sub.3                                                              6-(CH.sub.2).sub.3 CH(CH.sub.3).sub. 2                                                      6-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             114                                                                               6-(CH.sub.2).sub.6 CH.sub.3                                                              6-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             115                                                                               6-(CH.sub.2).sub.7 CH.sub.3                                                              6-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             116                                                                               6-(CH.sub.2).sub.8 CH.sub.3                                                              6-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             117                                                                               6-(CH.sub.2).sub.9 CH.sub.3                                                              6-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             118                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             119                                                                               6-(CH.sub.2).sub.15 CH.sub.3                                                             6-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      6-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             120                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2              __________________________________________________________________________                               CH.sub.3                                        

                                      TABLE 4                                      __________________________________________________________________________     Column 1     Column 2     Column 3                                             __________________________________________________________________________     Z = O, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                   1 H         5-(4-Cl--Ph) 5-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         2 5-Cl      5-(4-F--Ph)  5-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         3 5-F       5-CH.sub.2 Ph                                                                               5-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        4 5-Br      5-CH.sub.2 CH.sub.2 Ph                                                                      5-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        5 5-CF.sub.3                                                                               5-CH.sub.2 Ph-4-F                                                                           5-OCH.sub.2 Ph-4-F                                    6 5-Ph      5-CH.sub.2 Ph-4-Cl                                                                          5-OCH.sub.2 CH.sub.2 Ph-4-F                           7 5-Py      5-CH.sub.2 Ph-4-CF.sub.3                                                                    5-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         8 5-OPh     5-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          5-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        9 5-SPh     5-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   5-CH.sub.2 CH═CH--CH.sub.2 Ph                    10 5-OPy     5-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   5-OCH.sub.2 CH═CH--CH.sub.2 Ph                   11 6-Cl      6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        12 6-CF.sub.3                                                                               6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       13 6-Ph      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          14 6-OPh     6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        15 5-O(CH.sub.2).sub.5 CH.sub.3                                                             5-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             16 5-O(CH.sub.2).sub.6 CH.sub.3                                                             5-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             17 5-O(CH.sub.2).sub.7 CH.sub.3                                                             5-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             18 5-O(CH.sub.2).sub.8 CH.sub.3                                                             5-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             19 5-O(CH.sub.2).sub.9 CH.sub.3                                                             5-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub. 6 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             20 5-O(CH.sub.2).sub.11 CH.sub.3                                                            5-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             21 5-O(CH.sub.2).sub.15 CH.sub.3                                                            5-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     5-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             22 6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             23 5-(CH.sub.2).sub.5 CH.sub.3                                                              5-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             24 5-(CH.sub.2).sub.6 CH.sub.3                                                              5-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             25 5-(CH.sub.2).sub.7 CH.sub.3                                                              5-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             26 5-(CH.sub.2).sub.8 CH.sub.3                                                              5-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             27 5-(CH.sub.2).sub.9 CH.sub.3                                                              5-(CH.sub.2).sub. 7 CH(CH.sub.3).sub.2                                                      5-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             28 5-(CH.sub.2).sub.11 CH.sub.3                                                             5-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             29 5-(CH.sub.2).sub.15 CH.sub.3                                                             5-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      5-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             30 6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-Cl, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =               31 H         5-(4-Cl--Ph) 5-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        32 5-Cl      5-(4-F--Ph)  5-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        33 5-F       5-CH.sub.2 Ph                                                                               5-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       34 5-Br      5-CH.sub.2 CH.sub.2 Ph                                                                      5-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3       35 5-CF.sub.3                                                                               5-CH.sub.2 Ph-4-F                                                                           5-OCH.sub.2 Ph-4-F                                   36 5-Ph      5-CH.sub.2 Ph-4-Cl                                                                          5-OCH.sub.2 CH.sub.2 Ph-4-F                          37 5-Py      5-CH.sub.2 Ph-4-CF.sub.3                                                                    5-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        38 5-OPh     5-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          5-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3       39 5-SPh     5-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   5-CH.sub.2 CH═CH--CH.sub.2 Ph                    40 5-OPy     5-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   5-OCH.sub.2 CH═CH--CH.sub.2 Ph                   41 6-Cl      6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        42 6-CF.sub.3                                                                               6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       43 6-Ph      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          44 6-OPh     6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        45 5-O(CH.sub.2).sub.5 CH.sub.3                                                             5-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             46 5-O(CH.sub.2).sub.6 CH.sub.3                                                             5-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             47 5-O(CH.sub.2).sub.7 CH.sub.3                                                             5-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             48 5-O(CH.sub.2).sub.8 CH.sub.3                                                             5-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             49 5-O(CH.sub.2).sub.9 CH.sub.3                                                             5-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             50 5-O(CH.sub.2).sub.11 CH.sub.3                                                            5-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             51 5-O(CH.sub.2).sub.15 CH.sub.3                                                            5-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     5-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             52 6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             53 5-(CH.sub.2).sub.5 CH.sub.3                                                              5-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             54 5-(CH.sub.2).sub.6 CH.sub.3                                                              5-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub. 3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             55 5-(CH.sub.2).sub.7 CH.sub.3                                                              5-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             56 5-(CH.sub.2).sub.8 CH.sub.3                                                              5-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             57 5-(CH.sub.2).sub.9 CH.sub.3                                                              5-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             58 5-(CH.sub.2).sub.11 CH.sub.3                                                             5-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             59 5-(CH.sub.2).sub.15 CH.sub.3                                                             5-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      5-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             60 6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-F, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                61 H         5-(4-Cl--Ph) 5-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        62 5-Cl      5-(4-F--Ph)  5-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        63 5-F       5-CH.sub.2 Ph                                                                               5-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       64 5-Br      5-CH.sub.2 CH.sub.2 Ph                                                                      5-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3       65 5-CF.sub.3                                                                               5-CH.sub.2 Ph-4-F                                                                           5-OCH.sub.2 Ph-4-F                                   66 5-Ph      5-CH.sub.2 Ph-4-Cl                                                                          5-OCH.sub.2 CH.sub.2 Ph-4-F                          67 5-Py      5-CH.sub.2 Ph-4-CF.sub.3                                                                    5-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        68 5-OPh     5-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          5-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3       69 5-SPh     5-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   5-CH.sub.2 CH═CH--CH.sub.2 Ph                    70 5-OPy     5-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   5-OCH.sub.2 CH═CH--CH.sub.2 Ph                   71 6-Cl      6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        72 6-CF.sub.3                                                                               6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       73 6-Ph      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          74 6-OPh     6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        75 5-O(CH.sub.2).sub.5 CH.sub.3                                                             5-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             76 5-O(CH.sub.2).sub.6 CH.sub.3                                                             5-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             77 5-O(CH.sub.2).sub.7 CH.sub.3                                                             5-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             78 5-O(CH.sub.2).sub.8 CH.sub.3                                                             5-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             79 5-O(CH.sub.2).sub.9 CH.sub.3                                                             5-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             80 5-O(CH.sub.2).sub.11 CH.sub.3                                                            5-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             81 5-O(CH.sub.2).sub.15 CH.sub.3                                                            5-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     5-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             82 6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             83 5-(CH.sub.2).sub.5 CH.sub.3                                                              5-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             84 5-(CH.sub.2).sub.6 CH.sub.3                                                              5-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             85 5-(CH.sub.2).sub.7 CH.sub.3                                                              5-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             86 5-(CH.sub.2).sub.8 CH.sub.3                                                              5-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             87 5-(CH.sub.2).sub.9 CH.sub.3                                                              5-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             88 5-(CH.sub.2).sub.11 CH.sub.3                                                             5-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             89 5-(CH.sub.2).sub.15 CH.sub.3                                                             5-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      5-(CH.sub.2).sub. 12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             90 6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2              __________________________________________________________________________                               CH.sub.3                                        

                                      TABLE 5                                      __________________________________________________________________________     Column 1     Column 2     Column 3                                             __________________________________________________________________________     Z = O, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                   1 H         5-(4-Cl--Ph) 5-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         2 5-Cl      5-(4-F--Ph)  5-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         3 5-F       5-CH.sub.2 Ph                                                                               5-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        4 5-Br      5-CH.sub.2 CH.sub.2 Ph                                                                      5-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        5 5-CF.sub.3                                                                               5-CH.sub.2 Ph-4-F                                                                           5-OCH.sub.2 Ph-4-F                                    6 5-Ph      5-CH.sub.2 Ph-4-Cl                                                                          5-OCH.sub.2 CH.sub.2 Ph-4-F                           7 5-Py      5-CH.sub.2 Ph-4-CF.sub.3                                                                    5-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         8 5-OPh     5-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          5-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        9 5-SPh     5-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   5-CH.sub.2 CH═CH--CH.sub.2 Ph                    10 5-OPy     5-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   5-OCH.sub.2 CH═CH--CH.sub.2 Ph                   11 6-Cl      6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        12 6-CF.sub.3                                                                               6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       13 6-Ph      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          14 6-OPh     6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        15 5-O(CH.sub.2).sub.5 CH.sub.3                                                             5-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             16 5-O(CH.sub.2).sub.6 CH.sub.3                                                             5-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             17 5-O(CH.sub.2).sub.7 CH.sub.3                                                             5-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             18 5-O(CH.sub.2).sub.8 CH.sub.3                                                             5-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             19 5-O(CH.sub.2).sub.9 CH.sub.3                                                             5-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub. 6 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             20 5-O(CH.sub.2).sub.11 CH.sub.3                                                            5-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             21 5-O(CH.sub.2).sub.15 CH.sub.3                                                            5-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     5-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             22 6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             23 5-(CH.sub.2).sub.5 CH.sub.3                                                              5-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             24 5-(CH.sub.2).sub.6 CH.sub.3                                                              5-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             25 5-(CH.sub.2).sub.7 CH.sub.3                                                              5-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             26 5-(CH.sub.2).sub.8 CH.sub.3                                                              5-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             27 5-(CH.sub.2).sub.9 CH.sub.3                                                              5-(CH.sub.2).sub. 7 CH(CH.sub.3).sub.2                                                      5-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             28 5-(CH.sub.2).sub.11 CH.sub.3                                                             5-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             29 5-(CH.sub.2).sub.15 CH.sub.3                                                             5-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      5-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             30 6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-Cl, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =               31 H         5-(4-Cl--Ph) 5-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        32 5-Cl      5-(4-F--Ph)  5-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        33 5-F       5-CH.sub.2 Ph                                                                               5-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       34 5-Br      5-CH.sub.2 CH.sub.2 Ph                                                                      5-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3       35 5-CF.sub.3                                                                               5-CH.sub.2 Ph-4-F                                                                           5-OCH.sub.2 Ph-4-F                                   36 5-Ph      5-CH.sub.2 Ph-4-Cl                                                                          5-OCH.sub.2 CH.sub.2 Ph-4-F                          37 5-Py      5-CH.sub.2 Ph-4-CF.sub.3                                                                    5-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        38 5-OPh     5-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          5-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3       39 5-SPh     5-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   5-CH.sub.2 CH═CH--CH.sub.2 Ph                    40 5-OPy     5-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   5-OCH.sub.2 CH═CH--CH.sub.2 Ph                   41 6-Cl      6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        42 6-CF.sub.3                                                                               6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       43 6-Ph      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          44 6-OPh     6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        45 5-O(CH.sub.2).sub.5 CH.sub.3                                                             5-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             46 5-O(CH.sub.2).sub.6 CH.sub.3                                                             5-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             47 5-O(CH.sub.2).sub.7 CH.sub.3                                                             5-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             48 5-O(CH.sub.2).sub.8 CH.sub.3                                                             5-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             49 5-O(CH.sub.2).sub.9 CH.sub.3                                                             5-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             50 5-O(CH.sub.2).sub.11 CH.sub.3                                                            5-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             51 5-O(CH.sub.2).sub.15 CH.sub.3                                                            5-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     5-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             52 6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             53 5-(CH.sub.2).sub.5 CH.sub.3                                                              5-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             54 5-(CH.sub.2).sub.6 CH.sub.3                                                              5-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub. 3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             55 5-(CH.sub.2).sub.7 CH.sub.3                                                              5-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             56 5-(CH.sub.2).sub.8 CH.sub.3                                                              5-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             57 5-(CH.sub.2).sub.9 CH.sub.3                                                              5-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             58 5-(CH.sub.2).sub.11 CH.sub.3                                                             5-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             59 5-(CH.sub.2).sub.15 CH.sub.3                                                             5-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      5-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             60 6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-F, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                61 H         5-(4-Cl--Ph) 5-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        62 5-Cl      5-(4-F--Ph)  5-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        63 5-F       5-CH.sub.2 Ph                                                                               5-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       64 5-Br      5-CH.sub.2 CH.sub.2 Ph                                                                      5-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3       65 5-CF.sub.3                                                                               5-CH.sub.2 Ph-4-F                                                                           5-OCH.sub.2 Ph-4-F                                   66 5-Ph      5-CH.sub.2 Ph-4-Cl                                                                          5-OCH.sub.2 CH.sub.2 Ph-4-F                          67 5-Py      5-CH.sub.2 Ph-4-CF.sub.3                                                                    5-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        68 5-OPh     5-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          5-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3       69 5-SPh     5-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   5-CH.sub.2 CH═CH--CH.sub.2 Ph                    70 5-OPy     5-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   5-OCH.sub.2 CH═CH--CH.sub.2 Ph                   71 6-Cl      6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        72 6-CF.sub.3                                                                               6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       73 6-Ph      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          74 6-OPh     6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        75 5-O(CH.sub.2).sub.5 CH.sub.3                                                             5-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             76 5-O(CH.sub.2).sub.6 CH.sub.3                                                             5-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             77 5-O(CH.sub.2).sub.7 CH.sub.3                                                             5-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             78 5-O(CH.sub.2).sub.8 CH.sub.3                                                             5-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             79 5-O(CH.sub.2).sub.9 CH.sub.3                                                             5-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             80 5-O(CH.sub.2).sub.11 CH.sub.3                                                            5-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             81 5-O(CH.sub.2).sub.15 CH.sub.3                                                            5-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     5-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             82 6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             83 5-(CH.sub.2).sub.5 CH.sub.3                                                              5-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             84 5-(CH.sub.2).sub.6 CH.sub.3                                                              5-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             85 5-(CH.sub.2).sub.7 CH.sub.3                                                              5-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             86 5-(CH.sub.2).sub.8 CH.sub.3                                                              5-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             87 5-(CH.sub.2).sub.9 CH.sub.3                                                              5-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             88 5-(CH.sub.2).sub.11 CH.sub.3                                                             5-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             89 5-(CH.sub.2).sub.15 CH.sub.3                                                             5-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      5-(CH.sub.2).sub. 12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             90 6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2              __________________________________________________________________________                               CH.sub.3                                        

                                      TABLE 6                                      __________________________________________________________________________     Column 1     Column 2     Column 3                                             __________________________________________________________________________     Z = O, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                   1 H         5-(4-Cl--Ph) 5-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         2 5-Cl      5-(4-F--Ph)  5-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         3 5-F       5-CH.sub.2 Ph                                                                               5-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        4 5-Br      5-CH.sub.2 CH.sub.2 Ph                                                                      5-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        5 5-CF.sub.3                                                                               5-CH.sub.2 Ph-4-F                                                                           5-OCH.sub.2 Ph-4-F                                    6 5-Ph      5-CH.sub.2 Ph-4-Cl                                                                          5-OCH.sub.2 CH.sub.2 Ph-4-F                           7 5-Py      5-CH.sub.2 Ph-4-CF.sub.3                                                                    5-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         8 5-OPh     5-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          5-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        9 5-SPh     5-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   5-CH.sub.2 CH═CH--CH.sub.2 Ph                     10                                                                               5-OPy     5-CH.sub. 2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                  5-OCH.sub.2 CH═CH--CH.sub.2 Ph                    11                                                                               6-Cl      6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         12                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        13                                                                               6-Ph      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3           14                                                                               6-OPh     6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         15                                                                               5-O(CH.sub.2).sub.5 CH.sub.3                                                             5-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              16                                                                               5-O(CH.sub.2).sub.6 CH.sub.3                                                             5-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              17                                                                               5-O(CH.sub.2).sub.7 CH.sub.3                                                             5-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              18                                                                               5-O(CH.sub.2).sub.8 CH.sub.3                                                             5-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              19                                                                               5-O(CH.sub.2).sub.9 CH.sub.3                                                             5-O(CH.sub. 2).sub.7 CH(CH.sub.3).sub.2                                                     5-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              20                                                                               5-O(CH.sub.2).sub.11 CH.sub.3                                                            5-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              21                                                                               5-O(CH.sub.2).sub.15 CH.sub.3                                                            5-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     5-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              22                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              23                                                                               5-(CH.sub.2).sub.5 CH.sub.3                                                              5-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              24                                                                               5-(CH.sub.2).sub.6 CH.sub.3                                                              5-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              25                                                                               5-(CH.sub.2).sub.7 CH.sub.3                                                              5-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              26                                                                               5-(CH.sub.2).sub.8 CH.sub.3                                                              5-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              27                                                                               5-(CH.sub.2).sub.9 CH.sub.3                                                              5-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              28                                                                               5-(CH.sub.2).sub.11 CH.sub.3                                                             5-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              29                                                                               5-(CH.sub.2).sub.15 CH.sub.3                                                             5-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      5-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              30                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-Cl, R.sup.2 =                  31                                                                               H         5-(4-Cl--Ph) 5-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         32                                                                               5-Cl      5-(4-F--Ph)  5-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         33                                                                               5-F       5-CH.sub.2 Ph                                                                               5-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        34                                                                               5-Br      5-CH.sub.2 CH.sub.2 Ph                                                                      5-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        35                                                                               5-CF.sub.3                                                                               5-CH.sub.2 Ph-4-F                                                                           5-OCH.sub.2 Ph-4-F                                    36                                                                               5-Ph      5-CH.sub.2 Ph-4-Cl                                                                          5-OCH.sub.2 CH.sub.2 Ph-4-F                           37                                                                               5-Py      5-CH.sub.2 Ph-4-CF.sub.3                                                                    5-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         38                                                                               5-OPh     5-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          5-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        39                                                                               5-SPh     5-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   5-CH.sub.2 CH═CH--CH.sub.2 Ph                     40                                                                               5-OPy     5-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   5-OCH.sub.2 CH═CH--CH.sub.2 Ph                    41                                                                               6-Cl      6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         42                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        43                                                                               6-Ph      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3           44                                                                               6-OPh     6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         45                                                                               5-O(CH.sub.2).sub.5 CH.sub.3                                                             5-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      5-O(CH.sub. 2).sub.2 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              46                                                                               5-O(CH.sub.2).sub.6 CH.sub.3                                                             5-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              47                                                                               5-O(CH.sub.2).sub.7 CH.sub.3                                                             5-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              48                                                                               5-O(CH.sub.2).sub.8 CH.sub.3                                                             5-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              49                                                                               5-O(CH.sub.2).sub.9 CH.sub.3                                                             5-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              50                                                                               5-O(CH.sub.2).sub.11 CH.sub.3                                                            5-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              51                                                                               5-O(CH.sub.2).sub.15 CH.sub.3                                                            5-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     5-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              52                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                               53                                                                              5-(CH.sub.2).sub.5 CH.sub.3                                                              5-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              54                                                                               5-(CH.sub.2).sub.6 CH.sub.3                                                              5-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              55                                                                               5-(CH.sub.2).sub.7 CH.sub.3                                                              5-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              56                                                                               5-(CH.sub.2).sub.8 CH.sub.3                                                              5-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              57                                                                               5-(CH.sub.2).sub.9 CH.sub.3                                                              5-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              58                                                                               5-(CH.sub.2).sub.11 CH.sub.3                                                             5-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              59                                                                               5-(CH.sub.2).sub.15 CH.sub.3                                                             5-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      5-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              60                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-Cl, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                61                                                                               H         5-(4-Cl--Ph) 5-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         62                                                                               5-Cl      5-(4-F--Ph)  5-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         63                                                                               5-F       5-CH.sub.2 Ph                                                                               5-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        64                                                                               5-Br      5-CH.sub.2 CH.sub.2 Ph                                                                      5-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        65                                                                               5-CF.sub.3                                                                               5-CH.sub.2 Ph-4-F                                                                           5-OCH.sub.2 Ph-4-F                                    66                                                                               5-Ph      5-CH.sub.2 Ph-4-Cl                                                                          5-OCH.sub.2 CH.sub.2 Ph-4-F                           67                                                                               5-Py      5-CH.sub.2 Ph-4-CF.sub.3                                                                    5-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         68                                                                               5-OPh     5-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          5-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        69                                                                               5-SPh     5-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   5-CH.sub.2 CH═CH--CH.sub.2 Ph                     70                                                                               5-OPy     5-CH.sub. 2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                  5-OCH.sub.2 CH═CH--CH.sub.2 Ph                    71                                                                               6-Cl      6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         72                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        73                                                                               6-Ph      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3           74                                                                               6-OPh     6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         75                                                                               5-O(CH.sub.2).sub.5 CH.sub.3                                                             5-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              76                                                                               5-O(CH.sub.2).sub.6 CH.sub.3                                                             5-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              77                                                                               5-O(CH.sub.2).sub.7 CH.sub.3                                                             5-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              78                                                                               5-O(CH.sub.2).sub.8 CH.sub.3                                                             5-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              79                                                                               5-O(CH.sub.2).sub.9 CH.sub.3                                                             5-O(CH.sub. 2).sub.7 CH(CH.sub.3).sub.2                                                     5-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              80                                                                               5-O(CH.sub.2).sub.11 CH.sub.3                                                            5-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              81                                                                               5-O(CH.sub.2).sub.15 CH.sub.3                                                            5-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     5-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              82                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              83                                                                               5-(CH.sub.2).sub.5 CH.sub.3                                                              5-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              84                                                                               5-(CH.sub.2).sub.6 CH.sub.3                                                              5-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              85                                                                               5-(CH.sub.2).sub.7 CH.sub.3                                                              5-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              86                                                                               5-(CH.sub.2).sub.8 CH.sub.3                                                              5-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              87                                                                               5-(CH.sub.2).sub.9 CH.sub.3                                                              5-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              88                                                                               5-(CH.sub.2).sub.11 CH.sub.3                                                             5-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              89                                                                               5-(CH.sub.2).sub.15 CH.sub.3                                                             5-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      5-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              90                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-F, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                 91                                                                               H         5-(4-Cl--Ph) 5-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         92                                                                               5-Cl      5-(4-F--Ph)  5-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         93                                                                               5-F       5-CH.sub.2 Ph                                                                               5-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        94                                                                               5-Br      5-CH.sub.2 CH.sub.2 Ph                                                                      5-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        95                                                                               5-CF.sub.3                                                                               5-CH.sub.2 Ph-4-F                                                                           5-OCH.sub.2 Ph-4-F                                    96                                                                               5-Ph      5-CH.sub.2 Ph-4-Cl                                                                          5-OCH.sub.2 CH.sub.2 Ph-4-F                           97                                                                               5-Py      5-CH.sub.2 Ph-4-CF.sub.3                                                                    5-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         98                                                                               5-OPh     5-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          5-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        99                                                                               5-SPh     5-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   5-CH.sub.2 CH═CH--CH.sub.2 Ph                    100                                                                               5-OPy     5-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   5-OCH.sub.2 CH═CH--CH.sub.2 Ph                   101                                                                               6-Cl      6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        102                                                                               6-CF.sub.3                                                                               6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       103                                                                               6-Ph      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          104                                                                               6-OPh     6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        105                                                                               5-O(CH.sub.2).sub.5 CH.sub.3                                                             5-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub. 2                                      CH.sub.3                                             106                                                                               5-O(CH.sub.2).sub.6 CH.sub.3                                                             5-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             107                                                                               5-O(CH.sub.2).sub.7 CH.sub.3                                                             5-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             108                                                                               5-O(CH.sub.2).sub.8 CH.sub.3                                                             5-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             109                                                                               5-O(CH.sub.2).sub.9 CH.sub.3                                                             5-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             110                                                                               5-O(CH.sub.2).sub.11 CH.sub.3                                                            5-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             111                                                                               5-O(CH.sub.2).sub.15 CH.sub.3                                                            5-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     5-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             112                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             113                                                                               5-(CH.sub.2).sub.5 CH.sub.3                                                              5-(CH.sub.2).sub.3 CH(CH.sub.3).sub. 2                                                      5-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             114                                                                               5-(CH.sub.2).sub.6 CH.sub.3                                                              5-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             115                                                                               5-(CH.sub.2).sub.7 CH.sub.3                                                              5-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             116                                                                               5-(CH.sub.2).sub.8 CH.sub.3                                                              5-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             117                                                                               5-(CH.sub.2).sub.9 CH.sub.3                                                              5-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             118                                                                               5-(CH.sub.2).sub.11 CH.sub.3                                                             5-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             119                                                                               5-(CH.sub.2).sub.15 CH.sub.3                                                             5-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      5-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             120                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-F, R.sup.3 = 2'-F, R.sup.4 = 6'-Cl, R.sup.2 =               121                                                                               H         5-(4-Cl--Ph) 5-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        122                                                                               5-Cl      5-(4-F--Ph)  5-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        123                                                                               5-F       5-CH.sub.2 Ph                                                                               5-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       124                                                                               5-Br      5-CH.sub.2 CH.sub.2 Ph                                                                      5-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3       125                                                                               5-CF.sub.3                                                                               5-CH.sub.2 Ph-4-F                                                                           5-OCH.sub.2 Ph-4-F                                   126                                                                               5-Ph      5-CH.sub.2 Ph-4-Cl                                                                          5-OCH.sub.2 CH.sub.2 Ph-4-F                          127                                                                               5-Py      5-CH.sub.2 Ph-4-CF.sub.3                                                                    5-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        128                                                                               5-OPh     5-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          5-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3       129                                                                               5-SPh     5-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   5-CH.sub.2 CH═CH--CH.sub.2 Ph                    130                                                                               5-OPy     5-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   5-OCH.sub.2 CH═CH--CH.sub.2 Ph                   131                                                                               6-Cl      6-(4-Cl--Ph) 6-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        132                                                                               6-CF.sub. 3                                                                              6-CH.sub.2 Ph                                                                               6-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       133                                                                               6-Ph      6-CH.sub.2 CH.sub.2 Ph                                                                      6-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          134                                                                               6-OPh     6-CH.sub.2 Ph-4-CF.sub.3                                                                    6-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        135                                                                               5-O(CH.sub.2).sub.5 CH.sub.3                                                             5-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             136                                                                               5-O(CH.sub.2).sub.6 CH.sub.3                                                             5-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             137                                                                               5-O(CH.sub.2).sub.7 CH.sub.3                                                             5-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             138                                                                               5-O(CH.sub.2).sub.8 CH.sub.3                                                             5-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             139                                                                               5-O(CH.sub.2).sub.9 CH.sub.3                                                             5-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             140                                                                               5-O(CH.sub.2).sub.11 CH.sub.3                                                            5-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      5-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub. 2                                      CH.sub.3                                             141                                                                               5-O(CH.sub.2).sub.15 CH.sub.3                                                            5-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     5-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             142                                                                               6-O(CH.sub.2).sub.11 CH.sub.3                                                            6-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      6-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             143                                                                               5-(CH.sub.2).sub.5 CH.sub.3                                                              5-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             144                                                                               5-(CH.sub.2).sub.6 CH.sub.3                                                              5-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             145                                                                               5-(CH.sub.2).sub.7 CH.sub.3                                                              5-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             146                                                                               5-(CH.sub.2).sub.8 CH.sub.3                                                              5-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             147                                                                               5-(CH.sub.2).sub.9 CH.sub.3                                                              5-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       5-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             148                                                                               5-(CH.sub.2).sub.11 CH.sub.3                                                             5-(CH.sub.2).sub.9 CH(CH.sub.3).sub. 2                                                      5-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             149                                                                               5-(CH.sub.2).sub.15 CH.sub.3                                                             5-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      5-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             150                                                                               6-(CH.sub.2).sub.11 CH.sub.3                                                             6-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       6-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2              __________________________________________________________________________                               CH.sub.3                                        

                                      TABLE 7                                      __________________________________________________________________________     Column 1     Column 2     Column 3                                             __________________________________________________________________________     Z = O, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                   1 H         7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         2 7-Cl      7-(4-F--Ph)  7-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         3 7-F       7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        4 7-Br      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        5 7-CF.sub.3                                                                               7-CH.sub.2 Ph-4-F                                                                           7-OCH.sub.2 Ph-4-F                                    6 7-Ph      7-CH.sub.2 Ph-4-Cl                                                                          7-OCH.sub.2 CH.sub.2 Ph-4-F                           7 7-Py      7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         8 7-OPh     7-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          7-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        9 7-SPh     7-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   7-CH.sub.2 CH═CH--CH.sub.2 Ph                    10 7-OPy     7-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   7-OCH.sub.2 CH═CH--CH.sub.2 Ph                   11 8-Cl      8-(4-Cl--Ph) 8-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        12 8-CF.sub.3                                                                               8-CH.sub.2 Ph                                                                               8-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       13 8-Ph      8-CH.sub.2 CH.sub.2 Ph                                                                      8-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          14 8-OPh     8-CH.sub.2 Ph-4-CF.sub.3                                                                    8-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        15 7-O(CH.sub.2).sub.5 CH.sub.3                                                             7-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             16 7-O(CH.sub.2).sub.6 CH.sub.3                                                             7-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             17 7-O(CH.sub.2).sub.7 CH.sub.3                                                             7-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             18 7-O(CH.sub.2).sub.8 CH.sub.3                                                             7-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             19 7-O(CH.sub.2).sub.9 CH.sub.3                                                             7-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub. 6 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             20 7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             21 7-O(CH.sub.2).sub.15 CH.sub.3                                                            7-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     7-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             22 8-O(CH.sub.2).sub.11 CH.sub.3                                                            8-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      8-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             23 7-(CH.sub.2).sub.5 CH.sub.3                                                              7-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             24 7-(CH.sub.2).sub.6 CH.sub.3                                                              7-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             25 7-(CH.sub.2).sub.7 CH.sub.3                                                              7-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             26 7-(CH.sub.2).sub.8 CH.sub.3                                                              7-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             27 7-(CH.sub.2).sub.9 CH.sub.3                                                              7-(CH.sub.2).sub. 7 CH(CH.sub.3).sub.2                                                      7-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             28 7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             29 7-(CH.sub.2).sub.15 CH.sub.3                                                             7-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      7-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             30 8-(CH.sub.2).sub.11 CH.sub.3                                                             8-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       8-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-Cl, R.sup.2 =                 31 H         7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        32 7-Cl      7-(4-F--Ph)  7-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        33 7-F       7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       34 7-Br      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3       35 7-CF.sub.3                                                                               7-CH.sub.2 Ph-4-F                                                                           7-OCH.sub.2 Ph-4-F                                   36 7-Ph      7-CH.sub.2 Ph-4-Cl                                                                          7-OCH.sub.2 CH.sub.2 Ph-4-F                          37 7-Py      7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        38 7-OPh     7-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          7-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3       39 7-SPh     7-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   7-CH.sub.2 CH═CH--CH.sub.2 Ph                    40 7-OPy     7-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   7-OCH.sub.2 CH═CH--CH.sub.2 Ph                   41 8-Cl      8-(4-Cl--Ph) 8-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        42 8-CF.sub.3                                                                               8-CH.sub.2 Ph                                                                               8-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       43 8-Ph      8-CH.sub.2 CH.sub.2 Ph                                                                      8-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          44 8-OPh     8-CH.sub.2 Ph-4-CF.sub.3                                                                    8-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        45 7-O(CH.sub.2).sub.5 CH.sub.3                                                             7-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             46 7-O(CH.sub.2).sub.6 CH.sub.3                                                             7-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             47 7-O(CH.sub.2).sub.7 CH.sub.3                                                             7-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             48 7-O(CH.sub.2).sub.8 CH.sub.3                                                             7-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             49 7-O(CH.sub.2).sub.9 CH.sub.3                                                             7-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             50 7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             51 7-O(CH.sub.2).sub.15 CH.sub.3                                                            7-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     7-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             52 8-O(CH.sub.2).sub.11 CH.sub.3                                                            8-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      8-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             53 7-(CH.sub.2).sub.5 CH.sub.3                                                              7-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             54 7-(CH.sub.2).sub.6 CH.sub.3                                                              7-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub. 3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             55 7-(CH.sub.2).sub.7 CH.sub.3                                                              7-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             56 7-(CH.sub.2).sub.8 CH.sub.3                                                              7-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             57 7-(CH.sub.2).sub.9 CH.sub.3                                                              7-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             58 7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             59 7-(CH.sub.2).sub.15 CH.sub.3                                                             7-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      7-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             60 8-(CH.sub.2).sub.11 CH.sub.3                                                             8-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       8-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-Cl, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =               61 H         7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        62 7-Cl      7-(4-F--Ph)  7-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        63 7-F       7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       64 7-Br      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3       65 7-CF.sub.3                                                                               7-CH.sub.2 Ph-4-F                                                                           7-OCH.sub.2 Ph-4-F                                   66 7-Ph      7-CH.sub.2 Ph-4-Cl                                                                          7-OCH.sub.2 CH.sub.2 Ph-4-F                          67 7-Py      7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        68 7-OPh     7-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          7-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3       69 7-SPh     7-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   7-CH.sub.2 CH═CH--CH.sub.2 Ph                    70 7-OPy     7-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   7-OCH.sub.2 CH═CH--CH.sub.2 Ph                   71 8-Cl      8-(4-Cl--Ph) 8-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        72 8-CF.sub.3                                                                               8-CH.sub.2 Ph                                                                               8-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       73 8-Ph      8-CH.sub.2 CH.sub.2 Ph                                                                      8-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          74 8-OPh     8-CH.sub.2 Ph-4-CF.sub.3                                                                    8-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        75 7-O(CH.sub.2).sub.5 CH.sub.3                                                             7-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             76 7-O(CH.sub.2).sub.6 CH.sub.3                                                             7-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             77 7-O(CH.sub.2).sub.7 CH.sub.3                                                             7-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             78 7-O(CH.sub.2).sub.8 CH.sub.3                                                             7-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             79 7-O(CH.sub.2).sub.9 CH.sub.3                                                             7-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             80 7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             81 7-O(CH.sub.2).sub.15 CH.sub.3                                                            7-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     7-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             82 8-O(CH.sub.2).sub.11 CH.sub.3                                                            8-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      8-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             83 7-(CH.sub.2).sub.5 CH.sub.3                                                              7-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             84 7-(CH.sub.2).sub.6 CH.sub.3                                                              7-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             85 7-(CH.sub.2).sub.7 CH.sub.3                                                              7-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             86 7-(CH.sub.2).sub.8 CH.sub.3                                                              7-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             87 7-(CH.sub.2).sub.9 CH.sub.3                                                              7-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             88 7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             89 7-(CH.sub.2).sub.15 CH.sub.3                                                             7-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      7-(CH.sub.2).sub. 12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             90 8-(CH.sub.2).sub.11 CH.sub.3                                                             8-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       8-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2              __________________________________________________________________________                               CH.sub.3                                        

                                      TABLE 8                                      __________________________________________________________________________     Column 1     Column 2     Column 3                                             __________________________________________________________________________     Z = O, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                   1 H         7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         2 7-Cl      7-(4-F--Ph)  7-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         3 7-F       7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        4 7-Br      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        5 7-CF.sub.3                                                                               7-CH.sub.2 Ph-4-F                                                                           7-OCH.sub.2 Ph-4-F                                    6 7-Ph      7-CH.sub.2 Ph-4-Cl                                                                          7-OCH.sub.2 CH.sub.2 Ph-4-F                           7 7-Py      7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         8 7-OPh     7-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          7-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        9 7-SPh     7-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   7-CH.sub.2 CH═CH--CH.sub.2 Ph                     10                                                                               7-OPy     7-CH.sub. 2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                  7-OCH.sub.2 CH═CH--CH.sub.2 Ph                    11                                                                               8-Cl      8-(4-Cl--Ph) 8-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         12                                                                               8-CF.sub.3                                                                               8-CH.sub.2 Ph                                                                               8-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        13                                                                               8-Ph      8-CH.sub.2 CH.sub.2 Ph                                                                      8-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3           14                                                                               8-OPh     8-CH.sub.2 Ph-4-CF.sub.3                                                                    8-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         15                                                                               7-O(CH.sub.2).sub.5 CH.sub.3                                                             7-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              16                                                                               7-O(CH.sub.2).sub.6 CH.sub.3                                                             7-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              17                                                                               7-O(CH.sub.2).sub.7 CH.sub.3                                                             7-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              18                                                                               7-O(CH.sub.2).sub.8 CH.sub.3                                                             7-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              19                                                                               7-O(CH.sub.2).sub.9 CH.sub.3                                                             7-O(CH.sub. 2).sub.7 CH(CH.sub.3).sub.2                                                     7-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              20                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              21                                                                               7-O(CH.sub.2).sub.15 CH.sub.3                                                            7-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     7-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              22                                                                               8-O(CH.sub.2).sub.11 CH.sub.3                                                            8-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      8-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              23                                                                               7-(CH.sub.2).sub.5 CH.sub.3                                                              7-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              24                                                                               7-(CH.sub.2).sub.6 CH.sub.3                                                              7-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              25                                                                               7-(CH.sub.2).sub.7 CH.sub.3                                                              7-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              26                                                                               7-(CH.sub.2).sub.8 CH.sub.3                                                              7-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              27                                                                               7-(CH.sub.2).sub.9 CH.sub.3                                                              7-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              28                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              29                                                                               7-(CH.sub.2).sub.15 CH.sub.3                                                             7-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      7-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              30                                                                               8-(CH.sub.2).sub.11 CH.sub.3                                                             8-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       8-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = H, R.sup.3 = 2'-F, R.sup.4 = 6'-Cl, R.sup.2 =                  31                                                                               H         7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         32                                                                               7-Cl      7-(4-F--Ph)  7-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         33                                                                               7-F       7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        34                                                                               7-Br      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        35                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph-4-F                                                                           7-OCH.sub.2 Ph-4-F                                    36                                                                               7-Ph      7-CH.sub.2 Ph-4-Cl                                                                          7-OCH.sub.2 CH.sub.2 Ph-4-F                           37                                                                               7-Py      7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         38                                                                               7-OPh     7-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          7-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        39                                                                               7-SPh     7-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   7-CH.sub.2 CH═CH--CH.sub.2 Ph                     40                                                                               7-OPy     7-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   7-OCH.sub.2 CH═CH--CH.sub.2 Ph                    41                                                                               8-Cl      8-(4-Cl--Ph) 8-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         42                                                                               8-CF.sub.3                                                                               8-CH.sub.2 Ph                                                                               8-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        43                                                                               8-Ph      8-CH.sub.2 CH.sub.2 Ph                                                                      8-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3           44                                                                               8-OPh     8-CH.sub.2 Ph-4-CF.sub.3                                                                    8-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         45                                                                               7-O(CH.sub.2).sub.5 CH.sub.3                                                             7-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      7-O(CH.sub. 2).sub.2 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              46                                                                               7-O(CH.sub.2).sub.6 CH.sub.3                                                             7-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              47                                                                               7-O(CH.sub.2).sub.7 CH.sub.3                                                             7-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              48                                                                               7-O(CH.sub.2).sub.8 CH.sub.3                                                             7-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              49                                                                               7-O(CH.sub.2).sub.9 CH.sub.3                                                             7-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              50                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              51                                                                               7-O(CH.sub.2).sub.15 CH.sub.3                                                            7-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     7-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              52                                                                               8-O(CH.sub.2).sub.11 CH.sub.3                                                            8-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      8-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                               53                                                                              7-(CH.sub.2).sub.5 CH.sub.3                                                              7-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              54                                                                               7-(CH.sub.2).sub.6 CH.sub.3                                                              7-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              55                                                                               7-(CH.sub.2).sub.7 CH.sub.3                                                              7-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              56                                                                               7-(CH.sub.2).sub.8 CH.sub.3                                                              7-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              57                                                                               7-(CH.sub.2).sub.9 CH.sub.3                                                              7-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              58                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              59                                                                               7-(CH.sub.2).sub.15 CH.sub.3                                                             7-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      7-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              60                                                                               8-(CH.sub.2).sub.11 CH.sub.3                                                             8-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       8-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-Cl, R.sup.3 = 2'-F, R.sup.4 = 6'-F, R.sup.2 =                61                                                                               H         7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         62                                                                               7-Cl      7-(4-F--Ph)  7-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         63                                                                               7-F       7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        64                                                                               7-Br      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        65                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph-4-F                                                                           7-OCH.sub.2 Ph-4-F                                    66                                                                               7-Ph      7-CH.sub.2 Ph-4-Cl                                                                          7-OCH.sub.2 CH.sub.2 Ph-4-F                           67                                                                               7-Py      7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         68                                                                               7-OPh     7-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          7-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        69                                                                               7-SPh     7-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   7-CH.sub.2 CH═CH--CH.sub.2 Ph                     70                                                                               7-OPy     7-CH.sub. 2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                  7-OCH.sub.2 CH═CH--CH.sub.2 Ph                    71                                                                               8-Cl      8-(4-Cl--Ph) 8-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         72                                                                               8-CF.sub.3                                                                               8-CH.sub.2 Ph                                                                               8-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        73                                                                               8-Ph      8-CH.sub.2 CH.sub.2 Ph                                                                      8-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3           74                                                                               8-OPh     8-CH.sub.2 Ph-4-CF.sub.3                                                                    8-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         75                                                                               7-O(CH.sub.2).sub.5 CH.sub.3                                                             7-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              76                                                                               7-O(CH.sub.2).sub.6 CH.sub.3                                                             7-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              77                                                                               7-O(CH.sub.2).sub.7 CH.sub.3                                                             7-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              78                                                                               7-O(CH.sub.2).sub.8 CH.sub.3                                                             7-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              79                                                                               7-O(CH.sub.2).sub.9 CH.sub.3                                                             7-O(CH.sub. 2).sub.7 CH(CH.sub.3).sub.2                                                     7-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              80                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              81                                                                               7-O(CH.sub.2).sub.15 CH.sub.3                                                            7-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     7-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                              82                                                                               8-O(CH.sub.2).sub.11 CH.sub.3                                                            8-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      8-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              83                                                                               7-(CH.sub.2).sub.5 CH.sub.3                                                              7-(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              84                                                                               7-(CH.sub.2).sub.6 CH.sub.3                                                              7-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              85                                                                               7-(CH.sub.2).sub.7 CH.sub.3                                                              7-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              86                                                                               7-(CH.sub.2).sub.8 CH.sub.3                                                              7-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              87                                                                               7-(CH.sub.2).sub.9 CH.sub.3                                                              7-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              88                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                              89                                                                               7-(CH.sub.2).sub.15 CH.sub.3                                                             7-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      7-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                              90                                                                               8-(CH.sub.2).sub.11 CH.sub.3                                                             8-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       8-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             Z = O, R.sup.1 = 8-Cl, R.sup.3 = 2'-F, R.sup.4 = 6'-Cl, R.sup.2 =               91                                                                               H         7-(4-Cl--Ph) 7-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3         92                                                                               7-Cl      7-(4-F--Ph)  7-CH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3         93                                                                               7-F       7-CH.sub.2 Ph                                                                               7-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        94                                                                               7-Br      7-CH.sub.2 CH.sub.2 Ph                                                                      7-OCH.sub.2 CH═CH(CH.sub.2).sub.2 CH.sub.3        95                                                                               7-CF.sub.3                                                                               7-CH.sub.2 Ph-4-F                                                                           7-OCH.sub.2 Ph-4-F                                    96                                                                               7-Ph      7-CH.sub.2 Ph-4-Cl                                                                          7-OCH.sub.2 CH.sub.2 Ph-4-F                           97                                                                               7-Py      7-CH.sub.2 Ph-4-CF.sub.3                                                                    7-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3         98                                                                               7-OPh     7-(4-CH.sub.3 (CH.sub.2).sub.4 Ph)                                                          7-OCH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        99                                                                               7-SPh     7-CH.sub.2 Ph-4-(CH.sub.2).sub.9 CH.sub.3                                                   7-CH.sub.2 CH═CH--CH.sub.2 Ph                    100                                                                               7-OPy     7-CH.sub.2 Ph-4-(CH.sub.2).sub.4 CH.sub.3                                                   7-OCH.sub.2 CH═CH--CH.sub.2 Ph                   101                                                                               8-Cl      8-(4-Cl--Ph) 8-CH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3        102                                                                               8-CF.sub.3                                                                               8-CH.sub.2 Ph                                                                               8-OCH.sub.2 CH═CH(CH.sub.2).sub.6 CH.sub.3       103                                                                               8-Ph      8-CH.sub.2 CH.sub.2 Ph                                                                      8-OCH.sub.2 CH--CH(CH.sub.2).sub.2 CH.sub.3          104                                                                               8-OPh     8-CH.sub.2 Ph-4-CF.sub.3                                                                    8-CH.sub.2 C.tbd.C--(CH.sub.2).sub.4 CH.sub.3        105                                                                               7-O(CH.sub.2).sub.5 CH.sub.3                                                             7-O(CH.sub.2).sub.3 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub. 2                                      CH.sub.3                                             106                                                                               7-O(CH.sub.2).sub.6 CH.sub.3                                                             7-O(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             107                                                                               7-O(CH.sub.2).sub.7 CH.sub.3                                                             7-O(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             108                                                                               7-O(CH.sub.2).sub.8 CH.sub.3                                                             7-O(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             109                                                                               7-O(CH.sub.2).sub.9 CH.sub.3                                                             7-O(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             110                                                                               7-O(CH.sub.2).sub.11 CH.sub.3                                                            7-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      7-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             111                                                                               7-O(CH.sub.2).sub.15 CH.sub.3                                                            7-O(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                     7-O(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                      CH.sub.3                                             112                                                                               8-O(CH.sub.2).sub.11 CH.sub.3                                                            8-O(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                      8-O(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             113                                                                               7-(CH.sub.2).sub.5 CH.sub.3                                                              7-(CH.sub.2).sub.3 CH(CH.sub.3).sub. 2                                                      7-(CH.sub.2).sub.2 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             114                                                                               7-(CH.sub.2).sub.6 CH.sub.3                                                              7-(CH.sub.2).sub.4 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.3 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             115                                                                               7-(CH.sub.2).sub.7 CH.sub.3                                                              7-(CH.sub.2).sub.5 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.4 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             116                                                                               7-(CH.sub.2).sub.8 CH.sub.3                                                              7-(CH.sub.2).sub.6 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.5 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             117                                                                               7-(CH.sub.2).sub.9 CH.sub.3                                                              7-(CH.sub.2).sub.7 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.6 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             118                                                                               7-(CH.sub.2).sub.11 CH.sub.3                                                             7-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       7-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2                                        CH.sub.3                                             119                                                                               7-(CH.sub.2).sub.15 CH.sub.3                                                             7-(CH.sub.2).sub.13 CH(CH.sub.3).sub.2                                                      7-(CH.sub.2).sub.12 CH(CH.sub.3)CH.sub.2                                       CH.sub.3                                             120                                                                               8-(CH.sub.2).sub.11 CH.sub.3                                                             8-(CH.sub.2).sub.9 CH(CH.sub.3).sub.2                                                       8-(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2              __________________________________________________________________________                               CH.sub.3                                        

FORMULATION/UTILITY

Compounds of this invention will generally be used in formulation with an agriculturally suitable carrier comprising a liquid or solid diluent. Useful formulations include dusts, granules, baits, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates, dry flowables and the like, consistent with the physical properties of the active ingredient, mode of application and environmental factors such as soil type, moisture and temperature. Sprayable formulations can be extended in suitable media and used at spray volumes from about one to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The formulations will typically contain effective amounts of active ingredient, diluent and surfactant within the following approximate ranges which add up 100 weight percent.

    ______________________________________                                                      Weight Percent                                                                 Active                                                                         Ingredient                                                                             Diluent   Surfactant                                      ______________________________________                                         Wettable Powders                                                                              25-90      0-74     1-10                                        Oil Suspensions,                                                                               5-50     40-95     0-15                                        Emulsions, Solutions,                                                          (including Emulsifiable                                                        Concentrates)                                                                  Dusts           1-25     70-99     0-5                                         Granules, Baits and Pellets                                                                   0.01-99      5-99.99                                                                               0-15                                        High Strength  90-99      0-10     0-2                                         Compositions                                                                   ______________________________________                                    

Typical solid diluents are described in Watkins, et al., Handbook of Insecticide Dust Diluents and Carriers, 2rid Ed., Dorland Books, Caldwell, New Jersey. Typical liquid diluents and solvents are described in Marsden, Solvents Guide, 2nd Ed., Interscience, New York, 1950. McCutcheon's Detergents and Emulsifiers Annual, Allured Publ. Corp., Ridgewood, New Jersey, as well as Sisely and Wood, Encyclopedia of Surface Active Agents, Chemical Publ. Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foam, caking, corrosion, microbiological growth, etc.

Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer mill or fluid energy mill. Water-dispersible granules can be produced by agglomerating a fine powder composition; see for example, Cross et al., Pesticide Formulations, Washington, D.C., (1988), pp 251-259. Suspensions are prepared by wet-milling; see, for example, U.S. Pat. No. 3,060,084. Granules and pellets can be made by spraying the active material upon preformed granular carriers or by agglomeration techniques. See Browning, "Agglomeration", Chemical Engineering, Dec. 4, 1967, pp 147-148, Perry's Chemical Engineer's Handbook, 4th Ed., McGraw-Hill, New York, (1963), pages 8-57 and following, and WO 91/13546.

For further information regarding the an of formulation, see U.S. Pat. No. 3,235,361, Col. 6, line 16 through Col. 7, line 19 and Examples 10-41; U.S. Pat. No. 3,309,192, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182; U.S. Pat. No. 2,891,855, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4; Klingman, Weed Control as a Science, John Wiley and Sons, Inc., New York, (1961), pp 81-96; and Hance et at., Weed Control Handbook, 8th Ed., Blackwell Scientific Publications, Oxford, (1989).

In the following Examples, all percentages are by weight and all formulations are worked up in conventional ways. Compound numbers refer to compounds in Index Table A.

    ______________________________________                                         Example A                                                                      Wettable Powder                                                                Compound 1               65.0%                                                 dodecylphenol polyethylene glycol ether                                                                  2.0%                                                 sodium ligninsulfonate    4.0%                                                 sodium silicoaluminate    6.0%                                                 montmorillonite (calcined)                                                                               23.0%.                                               Example B                                                                      Granule                                                                        Compound 1               10.0%                                                 attapulgite granules (low volatile                                                                       90.0%.                                               matter, 0.71/0.30 mm; U.S.S. No.                                               25-50 sieves)                                                                  Example C                                                                      Extruded Pellet                                                                Compound 1               25.0%                                                 anhydrous sodium sulfate 10.0%                                                 crude calcium ligninsulfonate                                                                            5.0%                                                 sodium alkylnaphthalenesulfonate                                                                         1.0%                                                 calcium/magnesium bentonite                                                                              59.0%.                                               Example D                                                                      Emulsifiable Concentrate                                                       Compound 1               20.0%                                                 blend of oil soluble sulfonates                                                                         10.0%                                                 and polyoxyethylene ethers                                                     isophorone                70.0%.                                               ______________________________________                                    

The compounds of this invention exhibit activity against a wide spectrum of foliar-feeding, fruit-feeding, seed-feeding, aquatic and soil-inhabiting arthropods (term "arthropods" includes insects, mites and nematodes) which are pests of growing and stored agronomic crops, forestry, greenhouse crops, ornamentals, nursery crops, stored food and fiber products, livestock, household, and public and animal health. Those skilled in the an will appreciate that not all compounds are equally effective against all pests. Nevertheless, all of the compounds of this invention display activity against pests that include: eggs, larvae and adults of the Order Lepidoptera; eggs, foliar-feeding, fruit-feeding, root-feeding, seed-feeding larvae and adults of the Order Coleoptera; eggs, matures and adults of the Orders Hemiptera and Homoptera; eggs, larvae, nymphs and adults of the Order Acari; eggs, immatures and adults of the Orders Thysanoptera, Orthoptera and Dermaptera; eggs, immatures and adults of the Order Diptera; and eggs, junveniles and adults of the Phylum Nematoda. The compounds of this invention are also active against pests of the Orders Hymenoptera, Isoptera, Siphonaptera, Blattaria, Thysanura and Pscoptera; pests belonging to the Class Arachnida and Phylum Platyhelminthes. The compounds are active against the following species: southern corn rootworm (Diabrotica undecimpunctata howardi), aster leafhopper (Mascrosteles fascifrons), boll weevil (Anthonomus grandis), fall armyworm (Spodoptera frugiperda), black bean aphid (Aphis fabae), tobacco budworm (Heliothis virescens), rice water weevil (Lissorhoptrus oryzophilus), rice leaf beetle (Oulema oryzae), whitebacked planthopper (Sogatella furcifera), green leafhopper (Nephotettix cincticeps), brown planthopper (Nilaparvata lugens), small brown planthopper (Laodelphax striatellus), rice stem borer (Chilo suppressalis), rice leafroller (Cnaphalocrocis medinalis), black rice stink bug (Scotinophara lurida), rice stink bug (Lagynotomus elongatus), rice bug (Leptocorisa chinensis), slender rice bug (Cletus puntiger), and southern green stink bug (Nezara viridula). The compounds are particularly active on mites, demonstrating ovicidal, larvicidal and chemosterilant activity against such families as Tetranychidae including Tetranychus urticae, Tetranychus cinnabarinus, Tetranychus medanieli. Tetranychus pacificus, Tetranychus turkestani, Byrobia rubrioculus, Panonychus ulmi, Panonychus citri, Eotetranychus carpini borealis. Eotetranychus, hicoriae, Eotetranychus sexmaculatus, Eotetranychus yumensis, Eotetranychus banksi and Oligonychus pratensis; Tenuipalpidae including Brevipalpus lewisi, Brevipalpus phoenicis, Brevipalpus californicus and Brevipalpus obovatus; Eriophyidae including Phyllocoptruta oleivora, Eriophyes sheldoni, Aculus cornutus, Epitrimerus pyri and Eriophyes mangiferae. See WO 90/10623 and WO 92/00673 for more detailed pest descriptions.

Compounds of this invention can also be mixed with one or more other insecticides, fungicides, nematocides, bactericides, acaricides, semiochemicals, repel/ants, attractants, pheromones, feeding stimulants or other biologically active compounds to form a multi-component pesticide giving an even broader spectrum of agricultural protection. Examples of other agricultural protectants with which compounds of this invention can be formulated are: insecticides such as avermectin B, monocrotophos, carbofuran, tetrachlorvinphos, malathion, parathion-methyl, methomyl, chlordimeform, diazinon, deltamethrin, oxamyl, fenvalerate, esfenvalerate, permethrin, profenofos, sulprofos, triflumuron, diflubenzuron, methoprene, buprofezin, thiodicarb, acephate, azinphosmethyl, chlorpyrifos, dimethoate, fipronil, flufenprox, fonophos, isofenphos, methidathion, metha-midophos, phosmet, phosphamidon, phosalone, pirimicarb, phorate, terbufos, trichlorfon, methoxychlor, bifenthrin, biphenate, cyfluthrin, fenpropathrin, fluva-linate, flucythrinate, tralomethrin, metalaldehyde and rotenone; fungicides such as carbendazim, thiuram, dodine, maneb, chloroneb, benomyl, cymoxanil, fenpropidine, fenpropimorph, triadimefon, captan, thiophanate-methyl, thiabendazole, phosethyl-Al, chlorothalonil, dichloran, metalaxyl, captafol, iprodione, oxadixyl, vinclozolin, kasugamycin, myclobutanil, tebuconazole, difenoconazole, diniconazole, fluquinconazole, ipconazole, metconazole, penconazole, propiconazole, uniconzole, flutriafol, prochloraz, pyrifenox, fenarimol, triadimenol, diclobutrazol, copper oxychloride, furalaxyl, folpet, flusilazol, blasticidin S, diclomezine, edifenphos, isoprothiolane, iprobenfos, mepronil, neo-asozin, pencycuron, probenazole, pyroquilon, tricyclazole, validamycin, and flutolanil; nematocides such as aldoxycarb, fenamiphos and fosthietan; bactericides such as oxytetracyline, streptomycin and tribasic copper surf ate; acaricides such as binapacryl, oxythioquinox, chlorobenzilate. dicofol, dienochlor, cyhexatin, hexythiazox, amitraz, propargite, tebufenpyrad and fenbutatin oxide: and biological agents such as Bacillus thuringiensis and baculovirus.

In certain instances, combinations with other arthropodicides having a similar spectrum of control but a different mode of action will be particularly advantageous for resistance management.

Arthropod pests are controlled and protection of agronomic crops, animal and human health is achieved by applying one or more of the compounds of this invention, in an effective amount, to the environment of the pests including the agronomic and/or nonagronomic locus of infestation, to the area to be protected, or directly on the pests to be controlled. Thus, the present invention further comprises a method for the control of foliar and soil inhabiting arthropods and nematode pests and protection of agronomic and/or nonagronomic crops, comprising applying one or more of the compounds of Formula I, or compositions containing at least one such compound, in an effective amount, to the environment of the pests including the agronomic and/or nonagronomic locus of infestation, to the area to be protected, or directly on the pests to be controlled. A preferred method of application is by spraying. Alternatively, granular formulations of these compounds can be applied to the plant foliage or the soil. Other methods of application include direct and residual sprays, aerial sprays, seed coats, systemic uptake, baits, eartags, boluses, foggers, fumigants, aerosols, and many others. The compounds can be incorporated into baits that are consumed by the arthropods or in devices such as traps and the like.

The compounds of this invention can be applied in their pure state, but most often application will be of a formulation comprising one or more compounds with suitable careers, diluents, and surfactants and possibly in combination with a food depending on the contemplated end use. A preferred method of application involves spraying a water dispersion or refined off solution of the compounds. Combinations with spray oils, spray off concentrations, spreader stickers, adjuvants, and synergists and other solvents such as piperonyl butoxide often enhance compound efficacy.

The rate of application required for effective control will depend on such factors as the species of arthropod to be controlled, the pest's life cycle, life stage, its size, location, time of year, host crop or animal, feeding behavior, mating behavior, ambient moisture, temperature, and the like. Under normal circumstances, application rates of about 0.01 to 2 kg of active ingredient per hectare are sufficient to control pests in agronomic ecosystems, but as little as 0.001 kg/hectare may be sufficient or as much as 8 kg hectare may be required. For nonagronomic applications, effective use rates will range from about 1.0 to 50 rag/square meter but as little as 0.1 rag/square meter may be sufficient or as much as 150 mg/square meter may be required.

The following Tests demonstrate the control efficacy of compounds of this invention on specific pests. The pest control protection afforded by the compounds is not limited, however, to these species. See Index Tables A and B for compound descriptions.

                  Index TABLE A                                                    ______________________________________                                          ##STR10##                                                                     Cmpd #     R.sup.2    Physical Properties                                      ______________________________________                                         1          CH.sub.3 O 64-67° C.                                         2          CH.sub.3 (CH.sub.2).sub.4 O                                                               oil                                                      3          CH.sub.3 (CH.sub.2).sub.5 O                                                               oil                                                      4          CH.sub.3 (CH.sub.2).sub.6 O                                                               oil                                                      5          CH.sub.3 (CH.sub.2).sub.7 O                                                               oil                                                      6          CH.sub.3 (CH.sub.2).sub.8 O                                                               oil                                                      7          CH.sub.3 (CH.sub.2).sub.9 O                                                               oil                                                      8          CH.sub.3 (CH.sub.2).sub.9 O                                                               125-131° C. (HCl Salt)                            9          CH.sub.3 (CH.sub.2).sub.10 O                                                              oil                                                      10         CH.sub.3 (CH.sub.2).sub.11 O                                                              oil                                                      11         CH.sub.3 (CH.sub.2).sub.11 O                                                              124-125° C. (HCl Salt)                            12         CH.sub.3 (CH.sub.2).sub.15 O                                                              67-68° C.                                         13         F.sub.3 CSO.sub.3                                                                         oil                                                      14         2,4-diClPh oil                                                      15         3-NO.sub.2Ph                                                                              oil                                                      ______________________________________                                    

                  Index TABLE B                                                    ______________________________________                                          ##STR11##                                                                     Cmpd #     R.sup.2     Physical Properties                                     ______________________________________                                         16         Br          144-148° C.                                      17         Ph          103-106° C.                                      18         2,4-diClPh  oil                                                     19         3,5-diClPh  oil                                                     20         3-CF.sub.3Ph                                                                               oil                                                     21         3-Cl, 4-FPh oil                                                     22         4-OMePh     50-52° C.                                        23         3-NO.sub.2Ph                                                                               63-64° C.                                        ______________________________________                                    

Two-Spotted Spider Mite (Tetranychus urticae)

A solution of the test compound was prepared by dissolving it in a minimum of acetone and then adding water containing a wetting agent until the concentration of the test Compound was 10 ppm. Two-week old red kidney bean plants infested with two-spotted spider mites eggs were sprayed to m-off with the test solution using a turntable sprayer. Plants were held in a chamber at 25° C. and 50% relative humidity. Seven days after spray, these compounds gave mortality levels of 80% or higher: 2, 3, 4, 5, 7, 10, 14. 

I claim:
 1. A compound of the formula ##STR12## wherein A is selected from the group a direct bond, and C₁ -C₃ straight or branched chain alkylene;G is selected from C₁ -C₃ straight or branched chain alkylene; the ring containing A and G has 5-7 members; Z is O; R¹ is selected from the group H, halogen, C₁ -C₆ alkyl, C₁ -C₆ alkoxy, C₁ -C₆ haloalkyl and C₁ -C₆ haloalkoxy; R² is selected from the group H, halogen, C₁ -C₁₆ alkyl, C₃ -C₇ cycloalkyl, C₄ -C₇ cycloalkylalkyl, C₁ -C₁₆ haloalkyl, C₂ -C₁₆ alkenyl, C₂ -C₁₆ haloalkenyl, C₂ -C₁₆ alkynyl, C₂ -C₁₆ haloalkynyl, C₂ -C₁₆ alkoxyalkoxy, OR⁵, R⁵ OC(O)--, R⁵ C(O)-- and ##STR13## W is selected from the group direct bond, S, O, C(═O), C(═O)O, C(═O)O--C₁ -C₂ alkylene, C₁ -C₄ alkylene, O--C₁ -C₄ alkylene and O--C₂ -C₄ alkenylene, wherein when W is O--C₁ -C₄ alkylene or O--C₂ -C₄ alkenylene, the oxygen atom can be attached to either aromatic ring and when W is C(═O)O or C(═O)O--C₁ -C₂, the C(═O) moiety can be attached to either aromatic ring; Q is selected from CH and N; R³ and R⁴ are independently selected from the group H, halogen, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₁ -C₆ haloalkoxy, C₁ -C₆ alkylthio, CN and NO₂ ; R⁵ is selected from the group H, C₃ -C₇ cycloalkyl, C₄ -C₁₆ cycloalkylalkyl, C₁ -C₁₆ alkyl, C₁ -C₁₆ haloalkyl, C₂ -C₁₆ alkenyl, C₂ -C₁₆ haloalkenyl, C₂ -C₁₆ alkynyl and C₂ -C₁₆ haloalkynyl; R⁶ is selected from the group halogen, C₁ -C₁₀ alkyl, C₁ -C₁₀ alkoxy, C₁ -C₁₀ haloalkyl, C₁ -C₁₀ haloalkoxy and Si(R⁷)(R⁸)R⁹ ; R⁷, R⁸ and R⁹ are independently C₁ -C₃ alkyl; and n is 0 or an integer from 1 to
 5. 2. A compound according to claim 1 whereinA is a direct bond; G is selected from the group C₂ -C₃ alkylene; R¹ is selected from the group H and halogen; and R³ and R⁴ are independently selected from the group H, F and Cl.
 3. A compound according to claim 2:2'-(2,6-difluorophenyl)-3,4-dihydro-6-octyloxyspiro-[naphthalene-1(2H),4'(5'H)-oxazole].
 4. An arthropodicidal composition comprising an arthropodicidally effective amount of a compound according to claim 1 and a carrier therefor.
 5. A method for controlling arthropods comprising applying to them or to their environment an effective amount of a compound according to claim
 1. 